II.1       Timeline: Evolution of the Brain 
                      Animal Type and Event (ccm = cubic centimeter) Years Since Appearance
Sponges have no nerve cells (neurons), no internal organs, and no means for locomotion. They are the most primitive and earliest multi-cellular animals that evolved from cell colonies.
Jellyfish have the first nerve cells that appear in the form of a simple net but with no central nervous system (the brain with a spinal cord). They arose after sponges.
Flatworms have the first rudimentary brain. They also have eyespots and the components of both sexes in one individual.
600,000,000
Fish appear that have a reptilian brain or central nervous system. It is a small brain enclosed in a brainpan and a spinal cord protected by a segmented spinal column (backbone). They are the first vertebrates, a group that would eventually include fishes, amphibians, reptiles, birds, and all mammals, thus, humans.    550,000,000
Amphibians further develop the reptilian brain. But the cerebellum, that part of the brain which coordinates muscular movement,  is a mere connecting band. They evolved from lobe-finned fishes. 380,000,000
Primitive tetrapods developed from a fish with a two-lobed brain. These vertebrates with four limbs include the birds, reptiles, and mammals. 365,000,000
Reptiles, during their adaptation to life on land, further developed their brain and it reached its most advanced stage about 80 million years later. 330,000,000
Mammals, while adapting to nocturnal life and competing with reptiles, developed the limbic system* as well as a neocortex** when they first appeared. They are warm-blooded and offspring are fed with milk secreted from the female mammary glands. Probably evolved from a group of now extinct mammal-like reptiles.

*Primitive part of the brain near the brain stem that is thought to control emotions, behavior, smell, etc. **The new outer part of the brain.

225,000,000
Birds have a small cerebral cortex (the gray outer portion of the brain).  195,000,000
Non-human primates, during their adaptation to diurnal (daylight) living and to a life in trees, developed the neocortex into an early primate brain. 65,000,000
Earliest hominoids (human-like ancestors), apes like Proconsul Africanus 23,000,000
Ardipithecus had a brain size of approx. 300 ccm 5,800,000
Australopithecines had a brain size of 310-530 ccm 4,200,000
Homo habilis  had a brain size of 580-750 ccm 2,200,000
Homo erectus  had a brain size 775-1225 ccm 1,800,000
Homo heidelbergensis had a brain size of 1100-1200 ccm. Earlier known as Homo sapiens archaic, he is the bridge between Homo erectus and modern humans. Neanderthals (brain size 1300-1500ccm) too were offspring but a separate species, thus, no interbreeding with humans. 600,000 to 300,000
Modern humans, Homo sapiens sapiens, have a brain of 1300-1400 ccm. Evolved from Homo heidelbergensis, they have about 25,000 genes that share a 98.4% similarity with their closest living evolutionary relative, the chimpanzee. However, the 1.6% dissimilarity took 5 million years to evolve and makes a world of difference. It yielded the higher mental functions, and through them, together with culture, the potential for becoming fully human. 200,000 to present